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您所在的位置:首頁 > 腫瘤科醫(yī)學(xué)進(jìn)展 > PNAS:受傷會喚醒休眠的致癌干細(xì)胞(2)

PNAS:受傷會喚醒休眠的致癌干細(xì)胞(2)

2011-02-15 13:14 閱讀:2036 來源:生物谷 作者:大*勒 責(zé)任編輯:大彌勒
[導(dǎo)讀] 一項研究發(fā)現(xiàn),擁有致癌突變的毛囊干細(xì)胞在皮膚受傷的情況下可能引發(fā)一種皮膚癌。科研人員已經(jīng)把人類基底細(xì)胞癌(一種有可能導(dǎo)致毀容的皮膚癌)與創(chuàng)傷恢復(fù)的缺陷聯(lián)系在了一起。毛囊干細(xì)胞幫助在受傷后再生組織,但是人們?nèi)匀徊惶宄鼈冊谝l(fā)腫瘤方面的作

 

  PNAS   doi: 10.1073/pnas.1013098108

 

  Wounding mobilizes hair follicle stem cells to form tumors

 

  Sunny Y. Wong and Jeremy F. Reiter1

 

  Abstract

 

  A wide variety of human cancers are associated with injury. Although stem cells participate in tissue regeneration after wounding, it is unclear whether these cells also contribute to epithelial tumors. Human basal cell carcinomas (BCCs) are associated with misactivation of Hedgehog (Hh) signaling, commonly through acquisition of mutations in Smoothened (Smo). We have found that expression of an activated form of Smo by stem cells of the hair-follicle bulge and secondary hair germ does not induce robust Hh signaling or produce BCCs. However, wounding recruits these cells from the follicle to the wound site, where downstream Hh signal transduction is derepressed, giving rise to superficial BCC-like tumors. These findings demonstrate that BCC-like tumors can originate from follicular stem cells and provide an explanation for the association between wounding and tumorigenesis.


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