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PREECLAMPSIA
Reinaldo Figueroa, MD
Winthrop-University Hospital

PREECLAMPSIA
Hypertensive disorder specific to pregnancy
affects nearly 6% of all pregnancies
a major cause of maternal and neonatal mortality and morbidity
15 to 20 % of maternal mortality in developed countries

PREECLAMPSIA
Severity ranges from:
a mild disorder (transient hypertension in the later part of the pregnancy) to
a life-threatening disorder with seizures, HELLP syndrome, fetal hypoxia, and growth retardation
more severe disease: 0.56 per 1000 deliveries

PREECLAMPSIA
Predisposes women to other serious complications:
placental abruption
acute renal failure
cerebral hemorrhage
disseminated intravascular coagulation
circulatory collapse

PREECLAMPSIA
The etiology is unknown
believed to be involved:
immune maladaptation
placental ischemia
oxidative stress
genetic susceptibility

PREECLAMPSIA
Classification of hypertension in pregnancy
Gestational hypertension
Preeclampsia / eclampsia
Chronic hypertension
Preeclampsia superimposed on chronic hypertension

PREECLAMPSIA
Definition of hypertension
a systolic blood pressure of 140 mmHg or above,
or a diastolic blood pressure of 90mmHg or above,
on two occasions 6 hours apart
Abnormal proteinuria
the excretion of 300 mg or more of protein in 24 hours

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